Note: This study is currently only recruiting patients in the hospital.
If you are interested in being notified if this study begins recruiting from the general population, please use the 'I Am Interested' button below.
ARRIVAL: Asthma study to see if taking FDA approved Tezepelumab can help lower inhaler use
Enrollment for this study is expected to close on Saturday, June 14, 2025
Overview
What we are studying
This Phase IIIb clinical research study is examining the FDA-approved drug Tezspire (Tezepelumab) in people with severe asthma. This is an open-label study so all eligible participants will be able to try Tezepelumab. The study aims to see if monthly injections of this biologic medication might allow asthma patients to reduce the use of their daily background controller inhalers.
Why it is important
The study team is looking to understand if treatment with Tezepelumab in patients with severe asthma could meaningully improve asthma symptoms and allow certain patients to decrease their inhaler use.
What we hope to accomplish
Administration of Tezepelumab to patients with severe asthma could result in a meaningful reduction in asthma attcaks, improvement in lung fuction and improvement in asthma control.
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Principal Investigator
Project Contact
Click I Am Interested "I Am Interested" "I Am Interested" to get started. If you have questions, contact:
Asthma Research Center
Who can participate
Who cannot participate
What you may be asked to do
Project activities may include:
- Survey
- Personal health tracking
- Blood draw
- Injection or IV
- Medication
- Office visit
- Biosample (e.g., saliva, urine, or stool)
Estimated Time Commitment
20 visits over 18 months
What You May Get
Participants will have at least 20 visits over an 18-month period. The study team will provide the Tezepelumab study drug at no cost. All participants will start the study using their own inhalers, but after a few months of injections they will be switched to Symbicort and Airsupra at no cost. Participants will be compensated up to $2200.
Location
Brigham and Women's Hospital
75 Francis Street; Boston, MA
Travel
- Accessible by public transportation
- Parking reimbursed
- Parking available
Travel and Parking Details
Vouchers will be provided to cover parking at BWH garages during study visits.
Additional Information
Study Phase
Phase 3: This project studies a drug or treatment that has already been studied for safety and effectiveness in both healthy volunteers and participants with specific diseases or conditions. It will gather more information about safety and effectiveness. It may look specifically at different groups of people, different dosages, or different combinations of medications or treatments.
Funding Source
- Industry