Note: This study is currently only recruiting patients in the hospital.

If you are interested in being notified if this study begins recruiting from the general population, please use the 'I Am Interested' button below.

Have you had chronic pain for over three months?

The purpose of this study is to learn whether the combination of two medications can help reduce chronic pain and prevent the development of a condition called opioid-induced hyperalgesia (OIH).

Massachusetts General Hospital Chronic Pain Pain Pain Relievers
7 visits over 10 weeks
Estimated Time Commitment
Male, Female, 18-70 years
May Be Eligible
Payment up to $300
May Be Offered
Blood draw, Medication, Office visit, Personal health tracking, Survey
May Be Required
 
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This project is not recruiting.

Overview

What we are studying

The purpose of this study is to see if taking morphine together with another medication called duloxetine (a.k.a. Cymbalta), can help reduce chronic pain and prevent the development of a condition called opioid-induced hyperalgesia (OIH). Morphine is an opioid, which is a type of medication that is used to relieve pain. Some chronic pain patients who are treated with opioids can feel more sensitive to pain over time. This is called OIH.


Why it is important


What we hope to accomplish

Principal Investigator

Jianren Mao, MD, PhD

Massachusetts General Hospital

Public Profile

Who can participate

You may qualify for this study if you:



  • Are an adult aged 18-70

  • Have had chronic neck or back pain for more than 3 months

  • Have not taken an opioid medication in the last 3 months

  • Have not taken duloxetine (Cymbalta) in the last 3 months

What you may be asked to do

Study activities include:



  • Taking study medications and/or placebo medications

  • Taking vital signs

  • Urine samples

  • 2 blood draws

  • Questionnaires

  • Pain and medication logs

  • Sensory testing

  • Temperature testing

  • Phone calls


Project activities may include:

  • Blood draw
  • Medication
  • Office visit
  • Personal health tracking
  • Survey

Estimated Time Commitment

7 visits over 10 weeks

What You May Get

Participants will recieve compensation for participation in the study. 

Location

MGH Center for Translational Research
101 Merrimac St. Suite 630 Boston MA 02114

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Travel

  • Accessible by public transportation
  • Parking reimbursed
  • Local travel reimbursed

Travel and Parking Details

Additional Information

Project Website

http://www.massgeneral.org/translationalpainresearch/


ClinicalTrials.gov Identifier

NCT03249558


Study Phase

Phase 4: This project studies a drug or treatment that has already been approved by the FDA and studied in both healthy volunteers and participants with specific diseases or conditions. It will gather more information about long term safety and will help to understand how the drug or treatment can be most effective.


Participating Institutions


Funding Source

  • NIH or Other Federal
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