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Note: This study is currently only recruiting patients in the hospital.

If you are interested in being notified if this study begins recruiting from the general population, please use the 'I Am Interested' button below.

Medication Study for Adults with High Blood Pressure

The purpose of this study is to see whether, in people with high blood pressure, the drug eplerenone can make the heart and blood vessels work better than the drug chlorthalidone. Both medications are FDA-approved.

10 visits over 12 months
Estimated Time Commitment
Male, Female, 18-75 years
May Be Eligible
Payment up to $1,525, Meals
May Be Offered
Blood draw, Injection or IV, Medication, Office visit, PET scan, Personal health tracking, Biosample (e.g., saliva, urine, or stool)
May Be Required
 
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Enrollment for this study is expected to close on Wednesday, September 10, 2025

What we are studying

We are studying whether a medication (eplerenone) will improve oxygen delivery to the heart better than a diuretic medication (chlorthalidone).


Why it is important

High blood pressure is an important factor contributing to heart disease. Even if someone controls their blood pressure, they are still at risk for heart problems, suggesting that there are other contributing factors besides blood pressure. Two of these potential factors are: 1) The ability of the small blood vessels in the heart to deliver blood to the heart muscle; and 2) The ability of the heart to use oxygen.


What we hope to accomplish

The results of this study may potentially help us identify a better way to better prevent heart disease in people with hypertension.

Principal Investigator

Gail K Adler, MD, PhD

Brigham and Women's Hospital

Public Profile

Project Contact

Click I Am Interested "I Am Interested" "I Am Interested" to get started. If you have questions, contact:

Gerol Fang
Study Coordinator

gfang@bwh.harvard.edu
(617) 732-4657

Adults ages 18-75 who have high blood pressure

If you have a history of kidney disease, lung disease, HIV, or if you are a current smoker, you will be excluded from the study.

You will be asked to participate in 2 screening visits to determine your eligibility for the study. For eligible individuals, you will be weaned off your current home blood pressure medications and placed on the blood pressure medication enalapril for 1-3 months. You will then be randomized to one of two study medications: eplerenone or chlorthalidone. You will take the medication you are assigned for 9 months total.  At the beginning and end of the 9 month period, you will come into BWH for a Pre-Treatment and a Post-Treatment Assessment, during which the study team will take blood and urine samples and take images of your heart. During the months you are on study drug, you will record your daily blood pressures and report them regularly to the study coordinator in order to monitor your health. During those 9 months, you will also come to BWH for 30-minute in-person safety checks at weeks 1, 3, 6, and months 3, 5, 7.


Project activities may include:

  • Blood draw
  • Injection or IV
  • Medication
  • Office visit
  • PET scan
  • Personal health tracking
  • Biosample (e.g., saliva, urine, or stool)

Estimated Time Commitment

10 visits over 12 months


You will be paid a stipend to compensate you for your time and participation. You will receive:


·         $25 for Screening Visit 1


·         $500 for completing the Pre-Treatment Assessment


·         $500 for completing the Post-Treatment Assessment


·         $500 bonus for completing the study


 


for a total of $1,525. We will also reimburse you for parking fees.

Brigham and Women's Hospital
221 Longwood Avenue; 75 Francis Street

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Travel

  • Parking reimbursed
  • Accessible by public transportation
  • Parking available

Travel and Parking Details


Participating Institutions


Funding Source

  • NIH or Other Federal
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