Note: This study is currently only recruiting patients in the hospital.

If you are interested in being notified if this study begins recruiting from the general population, please use the 'I Am Interested' button below.

Platform Clinical Trial for Systemic Sclerosis Associated with Interstitial Lung Disease (ILD)

We are studying if 2 investigational new therapies, Amlitelimab and Nerandomilast (BI 1015550), are effective in treating patients with systemic sclerosis associated with interstitial lung disease (SSc-ILD).

Massachusetts General Hospital Interstitial Lung Diseases Scleroderma
10 visits over 1 year
Estimated time commitment
Any Gender, 18-years or older
May be eligible
Payment up to $1,375
May be offered
Survey, Blood draw, Injection or IV, Office visit, CT scan, Biosample (e.g., saliva, urine, or stool), Biopsy, Medication
May be required
 

This study is detailed for informational purposes only and may not be recruiting from the public.

This study is not recruiting.

Who can participate


  • Be at least 18 years of age

  • Have diffuse systemic sclerosis (scleroderma) 

  • Have your first non-Raynaud's symptom of systemic sclerosis within the past 5 years

  • Have systemic sclerosis-related interstitial lung disease 

Who cannot participate


  • You are pregnant or breastfeeding, or plan to become pregnant 

  • Your partner is trying to become pregnant 

  • You have another autoimmune disease besides systemic sclerosis 

What participants may be asked to do

If you decide to participate in this study, it will take you a little over a year to complete. During this time, we will ask you to make 10 study visits to the Massachusetts General Hospital. Participants will undergo some of the following evaluations during the study: patient surveys about your health and disease, physical exam, skin assessment, blood and urine collection, EKG (heart rhythm tracing), lung function testing, CT scan of lungs, and an optional skin biopsy.


Project activities may include:

  • Survey
  • Blood draw
  • Injection or IV
  • Office visit
  • CT scan
  • Biosample (e.g., saliva, urine, or stool)
  • Biopsy
  • Medication

Estimated time commitment

10 visits over 1 year

What participants may get

$1375 for complete of the study or $125 per visit. 

Location

Massachusetts General Hospital
55 Fruit St, Boston MA 02114

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Travel

  • Parking available
  • Parking reimbursed
  • Local travel reimbursed
  • Out of state travel possibly reimbursed
  • Accessible by public transportation

Travel and Parking Details

Parking and travel costs will be reimbursed.

Additional information

Project Website

https://www.conquestssc-trial.org/


ClinicalTrials.gov Identifier

NCT06195072


Study phase

Phase 2: This project studies whether a medication or treatment works for people with a specific disease or condition. The drug or treatment has been studied for safety in healthy volunteers, but the project will continue to look at safety and short term side effects.


Participating institutions


Funding source

  • Foundation
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