Note: This study is currently only recruiting patients in the hospital.

If you are interested in being notified if this study begins recruiting from the general population, please use the 'I Am Interested' button below.

Unvaccinated? Get vaccinated against COVID-19!

The Systemic Allergic Reactions to SARS-CoV-2 Vaccination study is recruiting unvaccinated volunteers to receive one of the two mRNA vaccines - Pfizer BioNtech COVID-19 Vaccine or Moderna COVID-19 Vaccine.

Massachusetts General Hospital Brigham and Women's Hospital Allergy Infectious Diseases
3 visits over 2 months
Estimated Time Commitment
Male, Female, Transgender Female, Transgender Male, Nonbinary, Gender-expansive, 12-years or older
May Be Eligible
Payment up to $385
May Be Offered
Blood draw, Office visit, Personal health tracking, Injection or IV
May Be Required
 
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This project is not recruiting.

Who can participate

Unvaccinated individuals who are 12 years of age or older and either have a history of serious allergic reaction, have a mast cell disorder, or have a history of no severe allergies.


Healthy Volunteers

Healthy volunteers are eligible for this study

To be a healthy volunteer for this study you must have:



  • Not already recieved a COVID-19 Vaccine (J&J, Pfizer, or Moderna)

  • No history of atopic dermatitis in the last 10 years

  • No history of allergic asthma in the last 10 years

  • No history of chronic urticaria (hives) or angiodema (rapid swelling of the skin and mucous membranes)

  • No history of anaphylaxis

Who cannot participate

You have already recieved a Covid-19 Vaccine OR


You are pregnant, OR


You are under 12 years old

What you may be asked to do

 Participation could be as short as 29 days or as long as 64 days.


If you join the study, you will complete 2 to 4 clinic visits and have 3 to 4 phone calls over a period of 29 to 64 days, depending on which vaccine you receive and whether you get the additional placebo dose.


You will receive either the Pfizer-BioNTech or Moderna COVID-19 vaccine. Each vaccine requires two doses. If you don’t have a reaction to the first vaccine dose, you will receive the second vaccine dose.  Some subjects may also receive a dose of placebo (salt water). You will receive three shots total, if you receive a placebo shot.


Project activities may include:

  • Blood draw
  • Office visit
  • Personal health tracking
  • Injection or IV

Estimated Time Commitment

3 visits over 2 months

What You May Get

Participants will recieve $25 for the pre-screening phone call, $100 for each study visit, and $15 for each planned study call. Therefore, they will recieve $270 or $385 for completing the study; depending on their study treatment.

Location

Clinical Trials Hub
3rd Floor, 60 Fenwood Road, Boston, MA 02115

Map it!


Travel

  • Accessible by public transportation
  • Parking available

Travel and Parking Details

Additional Information

Project Website

http://www.covidvaccine-allergy.org


ClinicalTrials.gov Identifier

NCT04761822


Study Phase

Phase 2: This project studies whether a medication or treatment works for people with a specific disease or condition. The drug or treatment has been studied for safety in healthy volunteers, but the project will continue to look at safety and short term side effects.


Participating Institutions


Funding Source

  • NIH or Other Federal
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