Note: This study is currently only recruiting patients in the hospital.

If you are interested in being notified if this study begins recruiting from the general population, please use the 'I Am Interested' button below.

Paid research on depression and the brain

Researchers at McLean Hospital in Belmont MA are seeking participants for a research study examining the relationship between depression, behavior, and brain activity.

McLean Hospital Massachusetts General Hospital Depression
13 hours over 4 visits
Estimated Time Commitment
Any Gender, 18-45 years
May Be Eligible
Gift card up to $1,088.50, Payment up to $1,088.50
May Be Offered
Survey, Personal health tracking, Blood draw, Injection or IV, Office visit, MRI scan, PET scan, Biosample (e.g., saliva, urine, or stool)
May Be Required
 
I Am Interested I Am Interested I Am Interested

Enrollment for this study is expected to close on Thursday, November 20, 2025

Overview

What we are studying

Researchers at McLean Hospital in Belmont, MA are seeking right-handed participants between the ages of 18-45, either with no history of mental illness or with a history of depression, to understand depression and the brain, in particular, the role of the Nociceptin/Orphanin FQ receptor system. The study includes four sessions over 12 months, including an MRI/PET scan, and a total time commitment of up to 13 hours. If you are eligible to participate, you can receive up to $1088.50.


If you are interested in hearing more about this study, please fill out our screening survey at https://redcap.partners.org/redcap/surveys/?s=EXELHXLYEPRKJYJW


Why it is important


What we hope to accomplish

Principal Investigator

Diego Pizzagalli, PhD

McLean Hospital

Public Profile

Project Contact

Click I Am Interested "I Am Interested" "I Am Interested" to get started. If you have questions, contact:

Claire Anderson

mclrew41study@mgb.org
(617) 855-4290

Who can participate

Researchers at McLean Hospital in Belmont, MA are seeking right-handed participants between the ages of 18-45, either with no history of mental illness or with a history of depression. The study includes four sessions over 12 months, including an MRI/PET scan, and a total time commitment of up to 13 hours. 


Healthy Volunteers

Healthy volunteers are eligible for this study

Who cannot participate

The study involves several blood draws, so participants must not have a history of phobia or fainting due to blood procedures.

What you may be asked to do

Each participant will be asked to complete clinical interviews, questionnaires, computerized tasks, an fMRI scan, a PET scan, blood draws, and smartphone surveys.


Project activities may include:

  • Survey
  • Personal health tracking
  • Blood draw
  • Injection or IV
  • Office visit
  • MRI scan
  • PET scan
  • Biosample (e.g., saliva, urine, or stool)

Estimated Time Commitment

13 hours over 4 visits

What You May Get

Upon completion of the entire study, participants can earn up to $1,088.50.

Location


Travel

  • Accessible by public transportation
  • Parking available
  • Parking reimbursed
  • Local travel reimbursed

Travel and Parking Details

Additional Information

ClinicalTrials.gov Identifier

NCT05630963


Participating Institutions


Funding Source

  • NIH or Other Federal
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