Note: This study is currently only recruiting patients in the hospital.

If you are interested in being notified if this study begins recruiting from the general population, please use the 'I Am Interested' button below.

Do you have HIV and increased belly fat?

We are conducting a research study in men and women with HIV to determine whether a medication that reduces belly fat may also improve heart health.

Massachusetts General Hospital HIV
5 visits over 6 months
Estimated Time Commitment
Any Sex/Gender, 40-70 years
May Be Eligible
Payment up to $350, Meals
May Be Offered
Blood draw, Injection or IV, MRI scan
May Be Required
 
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This project is not recruiting.

Overview

What we are studying

Individuals with HIV are prone to an increased accumulation of fat in the abdomen as well as in tissues such as the heart. In the current study, we would like to assess whether a medication prescribed clinically to reduce belly fat (Tesamorelin) may also reduce fat in the heart and improve heart function.


Why it is important

Individuals with HIV are at an increased risk of abnormal functioning of the heart and heart failure compared to the general population. Fat accumulation is one cause of such heart abnormalities. While this is a common problem, there are no known therapies that prevent heart failure in people living with HIV.


What we hope to accomplish

This study tests whether the drug Tesamorelin can reduce heart fat and improve heart function in HIV. Thus, this study may identify a new drug to prevent heart failure in the HIV population.

Principal Investigator

Steven K Grinspoon, MD

Massachusetts General Hospital

Public Profile

Who can participate

Men and women, 40 - 70 years of age, with well-controlled HIV and belly fat accumulation.

What you may be asked to do

Participants will undergo an MRI of the heart to look at how well their heart functions. Participants will also undergo blood draws.


Project activities may include:

  • Blood draw
  • Injection or IV
  • MRI scan

Estimated Time Commitment

5 visits over 6 months

What You May Get

 Detailed health assessments, up to $350 compensation, meals/snacks, and reimbursement for travel.

Location

MGH Clinical Research Center (CRC) Massachusetts General Hospital
55 Fruit Street, White 12, Boston MA 02114

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Travel

  • Out of state travel possibly reimbursed
  • Local travel reimbursed
  • Accessible by public transportation
  • Parking reimbursed
  • Parking available

Travel and Parking Details

Additional Information

ClinicalTrials.gov Identifier

NCT03826160


Participating Institutions


Funding Source

  • Other
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