Note: This study is currently only recruiting patients in the hospital.
If you are interested in being notified if this study begins recruiting from the general population, please use the 'I Am Interested' button below.
Seeking Patients with Hypertrophic Cardiomyopathy and Healthy Endurance Athletes
This project is not recruiting.
Overview
What we are studying
For this study, we are studying how efficienctly the heart uses energy to do its work. We are comparing the results between healthy endurance athletes, healthy normal individuals, and patients with hypertrophic cardiomyopathy (HCM). We have had an outpouring of interest for healthy normal individuals, so now we are only looking for endurance athletes, or those with hypertrophic cardiomyopathy.
Why it is important
In HCM, the pumping chamber of the heart (left ventricle) is enlarged, due to a gene mutation. The same sort of heart enlargement can occur in athletes due to vigorous exercise. At times it is hard to tell the difference between the heart of a healthy athlete and that of a person with mild HCM. Distinguishing between the two forms of enlargement of the heart is very important because HCM is one of the leading causes of sudden death in young, active individuals. Existing heart testing sometimes cannot determine if heart enlargement is due to exercise or HCM.
What we hope to accomplish
In this study, we are comparing how the heart muscle uses energy among patients with HCM, healthy endurance athletes, and healthy individuals who are not vigorous exercisers. Our goal is to identify if the scans that evaluate heart energy use can tell the difference between heart enlargement due to exercise and due to HCM. This would allow us to better treat and manage patients with these conditions.
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Principal Investigator
Who can participate
We are seeking patients with hypertrophic cardiomyopathy, aged 18-50 years old. We are also seeking endurance athletes, defined as at least 10 hours per week of exercise of which the majority is dedicated to endurance training (i.e. cycling, rowing, running). If you are interested, but have questions regarding whether your activity levels are appropriate for this study, we welcome you to ask study staff.
Who cannot participate
Individuals with a known medical disease (including but not limited to other forms of heart disease, lunch disease, or diabetes) and individuals who are pregnant.
What you may be asked to do
Research procedures include an echocardiogram (heart ultrasound), placement of an intravenous (IV) catheter in the arm for a blood draw, a cardiac positron emission tomography (PET) scan (picture to see how the heart uses energy), and a cardiopulmonary exercise test (exercise test of the heart and lungs).
Project activities may include:
- Blood draw
- Injection or IV
- Office visit
- Ultrasound
- PET scan
Estimated Time Commitment
3 visits over 2 weeks
What You May Get
There will be financial compensation of $300 for participating in this study. Transportation costs (cab voucher or parking up to $20 per visit) will be provided, or the Mass General Brigham shuttle can be used.
Location
Brigham and Women's Hospital Shapiro Noninvasive Cardiovascular Imaging Center L1
75 Francis St, Floor L1, Boston MA
Massachusetts General Hospital Cardiovascular Performance Exercise Lab
Yawkey Center for Outpatient Care 5B-512 32 Fruit St, Boston MA, 02114
Travel
- Parking reimbursed
- Local travel reimbursed
- Parking available
- Accessible by public transportation
Travel and Parking Details
Additional Information
Funding Source
- NIH or Other Federal
- Department