Note: This study is currently only recruiting patients in the hospital.

If you are interested in being notified if this study begins recruiting from the general population, please use the 'I Am Interested' button below.

Want to be healthier by eating better? Join this research study to find out!

Help us combat the negative health effects caused by night work! By joining this study, you'll support the development of new dietary approaches to improve health.

Brigham and Women's Hospital Nutrition Metabolic Disorders Blood Glucose
2 visits over 16 weeks
Estimated Time Commitment
Male, Female, 18-45 years
May Be Eligible
Payment up to $4,000
May Be Offered
Overnight stay, Office visit, Injection or IV, Blood draw, Personal health tracking, Survey, Biosample (e.g., saliva, urine, or stool)
May Be Required
 
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Enrollment for this study is expected to close on Thursday, January 29, 2026

Overview

What we are studying

We are doing this research study to find out how a person’s genes and their behaviors influence the effect of night work on physiological (how the body works) changes that may link to the higher risks for diabetes, obesity, and cardiovascular diseases in night-shift workers. We also want to find out if certain dietary patterns can help prevent or lessen the negative health effects of night work.


Why it is important

Shift work increases the risk for type 2 diabetes (T2D), which cannot be fully explained by differences in lifestyle and socioeconomic status. Although dietary patterns have been shown to be linked to body weight and blood sugar changes after meal intake, such associations are still unclear in the context of night shift work. Hence, this study will aim to bring us closer to understanding how certain dietary patterns affect blood sugar regulation after meal intake.


What we hope to accomplish

Our long-term goal is to develop evidence-based dietary interventions to prevent or reduce the negative metabolic effects associated with night shift work.

Principal Investigator

Frank Scheer, PhD

Brigham and Women's Hospital

Public Profile

Contact

Click I Am Interested "I Am Interested" "I Am Interested" to get started. If you have questions, contact:

Mitigation Study Team

mcp_mitigation@bwh.harvard.edu
(617) 525-0522

Who can participate


  • 18 - 45 years of age

  • Body Mass Index (BMI) 20.0 - 29.9 kg/m2

  • European ancestry

  • Black or African Amercian ancestry

  • Hispanic or Latino ancestry


If you are interested in this study, please respond to our pre-screening survey: https://redcap.partners.org/redcap/surveys/?s=YLH7CXRHF7P3ELCT


 


Healthy Volunteers

Healthy volunteers are eligible for this study

A healthy volunteer is described as one who is/has...



  • drug-free

  • non-smoker

  • no alcohol dependency

  • no medical and psychological disorders

  • not on any medication (except oral contraceptives)

Who cannot participate


  • Currently smoking/vaping or 5 or more years of smoking/vaping

  • History of drug or alcohol dependency

  • Any acute, chronic or debilitating medical conditions (e.g. sleep disorders, metabolic, cardiovascular, respiratory, neurological, cancers, etc.)

  • History of psychiatric illnesses or disorders

  • Pregnant women

What you may be asked to do

Participants may be asked to complete the following:


Estimated time commitment: 11 - 16 weeks


Screening



  • Initial screening

  • Physical exam

  • Psychological screening


At-home ambulatory monitoring



  • Regular sleep/wake cycle

  • Call-ins or sleep/wake diaries

  • Meal-logging or meal diaries


Two In-laboratory visits (5 days each)



  • Simulated night shift

  • Standardized meals

  • Frequent blood samplings

  • Saliva, stool samplings, rectal swabs

  • Questionnaires


Project activities may include:

  • Overnight stay
  • Office visit
  • Injection or IV
  • Blood draw
  • Personal health tracking
  • Survey
  • Biosample (e.g., saliva, urine, or stool)

Estimated Time Commitment

2 visits over 16 weeks

What You May Get

Up to $4,000 plus travel compensation for completing the study. 

Location

Brigham and Women's Hospital
75 Francis Street, Boston, MA 02115

Map it!


Travel

  • Local travel reimbursed
  • Out of state travel possibly reimbursed
  • Parking reimbursed
  • Parking available
  • Accessible by public transportation

Travel and Parking Details

Participants have to travel to 221 Longwood Ave., Boston, MA, 02115 for the physical exam and research consent visit, and to Brigham and Women's main hospital for the in-labratory visits.

Additional Information

Project Website

https://redcap.partners.org/redcap/surveys/?s=YLH7CXRHF7P3ELCT


ClinicalTrials.gov Identifier

NCT04868526


Participating Institutions


Funding Source

  • NIH or Other Federal
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