Note: This study is currently only recruiting patients in the hospital.

If you are interested in being notified if this study begins recruiting from the general population, please use the 'I Am Interested' button below.

Effects of a Dietary Supplement on Metabolism, Muscle Performance, and Physical Function

This study will help researchers find out if an oral dietary supplement, NMN, is safe and whether it has any effect on metabolism, muscle performance, and physical function.

Brigham and Women's Hospital Women's Health Men's Health
28 hours over 4 months
Estimated Time Commitment
Male, Female, 45-years or older
May Be Eligible
Payment up to $1,700, Meals
May Be Offered
Blood draw, Office visit, MRI scan, Medication
May Be Required
 
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This project is not recruiting.

Overview

What we are studying

In this study, we want to find out if an oral dietary supplement, NMN, is safe to take without causing too many side effects. This study will also help us find out how this study supplement is metabolized (processed) in the body and if it has any effect on muscle performance, physical function, or aerobic endurance. NMN contains the nutrient called β-nicotinamide mononucleotide. NMN is a naturally occurring nutrient that is found in all living things and in various food products. Also, NMN is similar to the important B vitamin known as niacin. NMN is a nutritional supplement and not an FDA approved drug. It is sold as a nutritional supplement in the USA without FDA’s approval under the statute of the Dietary Supplement Health and Education Act (DSHEA). In this study, this supplement is NOT being used to evaluate the nutritional supplement’s ability to diagnose, cure, mitigate, treat, or prevent a disease. The clinical investigation is intended only to evaluate the effects of NMN on healthy volunteers. This research study will compare the study supplement, NMN to placebo. The placebo looks exactly like NMN, but contains no active drug. During this study, participants may get a placebo instead of NMN. Placebos are used in research studies to see if the results are due to the study drug or due to other reasons.


 


Why it is important


What we hope to accomplish

Principal Investigator

Shalender Bhasin, MD

Brigham and Women's Hospital

Public Profile

Who can participate

Healthy men and women, age 45 and older


Healthy Volunteers

Healthy volunteers are eligible for this study

What you may be asked to do

If you decide to join this research study, the following things will happen: You will undergo blood and urine sample collection, physical exams, electrocardiograms (ECG), magnetic resonance imaging (MRI), and physical function assessments


Project activities may include:

  • Blood draw
  • Office visit
  • MRI scan
  • Medication

Estimated Time Commitment

28 hours over 4 months

What You May Get

Participants will be paid for each visit they complete. Visit payments vary -- the total for completion of all study visits is $1700.  Participants will be given a meal voucher for each visit that requires fasting or is longer than 2 hours.

Location


Travel

  • Parking available
  • Parking reimbursed
  • Local travel reimbursed

Travel and Parking Details

Additional Information

Study Phase

Phase 1/2: This project studies the safety of a medication or treatment. It examines the medication or treatment’s effects on the body and looks for side effects. It may also examine whether the medication or treatment works for people with a specific disease or condition.


Participating Institutions


Funding Source

  • Industry
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