Note: This study is currently only recruiting patients in the hospital.

If you are interested in being notified if this study begins recruiting from the general population, please use the 'I Am Interested' button below.

Do you act out your dreams?

REM Sleep Behavior Disorder (RBD) is a disorder in which people talk or move during their dreaming sleep. We are actively recruiting individuals with REM Sleep Behavior Disorder RBD to participate in the NAPS Consortium.

Massachusetts General Hospital Sleep Disorders
2 visits over 2 years
Estimated Time Commitment
Male, Female, Transgender Female, Transgender Male, Nonbinary, Gender-expansive, Intersex, 18-years or older
May Be Eligible
Payment up to $100
May Be Offered
Blood draw, Office visit, Registry, Survey
May Be Required
 
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This project is not recruiting.

Overview

What we are studying

We are studying people who are diagnosed with RBD, enrolling the particiapnts into a registry, and collecting from them a standardized set of measurements about neurological functioning, blood samples, and other biomedical information.


Why it is important

Rapid Eye Movement (REM) sleep behavior disorder (RBD) is a rare sleep disorder in which people move and talk during their dreaming sleep. Some people with RBD develop another neurological disease, usually Parkinson’s Disease, Dementia with Lewy Bodies, or Multiple System atrophy—collectively termed synucleinopathies—within several years. Currently, there are no treatments to slow or prevent these neurodegenerative diseases, however, there are some promising treatments on the near horizon.


What we hope to accomplish

The goal of the North American Prodromal Synucleinopathy (NAPS) Consortium is to plan a clinical trial for treatments against neurodegenerative diseases in people with RBD. Ultimately, we hope to enroll our registry participants in a clinical trial for preventive treatments against synucleinopathies.

Principal Investigator

Aleksandar Videnovic, MD, PhD

Massachusetts General Hospital

Public Profile

Who can participate

The NAPS Consortium is recruiting people with Idiopathic RBD, meaning that the RBD is not due to any known cause. Therefore, if you have narcolepsy or another neurological disorder, you are not eligible for the study. You must be at least 18 years old to participate. 


If you think you might have RBD but it has not been diagnosed officially, you will need to see a sleep doctor at an accredited sleep center. Please contact us for information about sleep doctors near you.

Who cannot participate

Individuals who are not diagnosed with Idiopathic REM Sleep Behavior Disorder (RBD). 

What you may be asked to do


  • The estimated duration of each visit is 3-4 hours.

  • You will provide information about your medical history, and you will have a physical exam.

  • If you have a bed partner (someone who sleeps in the same bed as you) or live with someone, we prefer for that person to come to the visit as well to provide additional information.

  • You will fill out questionnaires about your medical and sleep history.

  • You will have testing of your memory, thinking, movements, and other neurological functions.

  • You will have a blood draw.

  • After the last study visit, your medical record will be followed for 10 years.


Project activities may include:

  • Blood draw
  • Office visit
  • Registry
  • Survey

Estimated Time Commitment

2 visits over 2 years

What You May Get

You will be compensated for your time and effort.

Location


Travel

  • Accessible by public transportation
  • Parking reimbursed
  • Out of state travel possibly reimbursed
  • Local travel reimbursed
  • Parking available

Travel and Parking Details

Charles River Plaza Parking Garage

Additional Information

Project Website

https://www.naps-rbd.org/


ClinicalTrials.gov Identifier

NCT03623672


Participating Institutions


Funding Source

  • NIH or Other Federal
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