Note: This study is currently only recruiting patients in the hospital.

If you are interested in being notified if this study begins recruiting from the general population, please use the 'I Am Interested' button below.

Neural Basis of Loneliness in Mental Illness - Individuals with Psychosis & Healthy Controls Needed!

This study investigates loneliness in people with and without psychosis. To measure this, participants will complete: bursts of surveys, an MRI of the brain, questions about their mental health, behavioral tasks, and a blood draw.

Massachusetts General Hospital Mental Health Psychotic Disorders
5 visits over 6 months
Estimated Time Commitment
Male, Female, Nonbinary, 18-55 years
May Be Eligible
Payment up to $730
May Be Offered
Survey, Personal health tracking, Blood draw, MRI scan, Office visit
May Be Required
 
I Am Interested I Am Interested I Am Interested

Enrollment for this study is expected to close on Friday, January 16, 2026

Who can participate

Individuals who are 18-55 years old who have experienced psychosis while experiencing a psychiatric disorder like schizophrenia, schizoaffective disorder, bipolar disorder, or major depressive disorder. 


Additionally, individuals who are 18-55 years old who have no history of major mental illness or a psychotic episode and no first-degree relatives with a history of a psychotic illness can participate.


Please fill out the following screening survey to determine eligibility: https://redcap.partners.org/redcap/surveys/?s=N8FLEH4WWRMTPJEP


Healthy Volunteers

Healthy volunteers are eligible for this study

Individuals who are 18-55 years old who have no history of major mental illness, have never experienced psychosis, and do not have a first-degree relative with a history of a psychotic illness can participate. 

Who cannot participate

If you have any metal implants or may be pregnant, you are not eligible for the study. If you have recently changed medications or have a current substance use disorder, you may not be eligible. 

What you may be asked to do

In this study, which consists of five visits, you will complete some cognitive and behavioral tasks, answer some questionnaires and surveys, receive a magnetic resonance imaging (MRI) scan, and complete a health assessment, including getting your blood drawn. You will complete simple tasks while watching a number of faces on a screen during the MRI scan. You will be compensated up to $730 for the study.



Study activities may include:



  • Office visits

  • MRI scan

  • Surveys

  • Blood draws


Project activities may include:

  • Survey
  • Personal health tracking
  • Blood draw
  • MRI scan
  • Office visit

Estimated Time Commitment

5 visits over 6 months

What You May Get

Compensation will be up to $730 for completion of all parts of the study. 

Location

Martinos Center for Biomedical Imaging
149 13th St.

Map it!


Travel

  • Local travel reimbursed
  • Parking reimbursed
  • Parking available
  • Out of state travel possibly reimbursed
  • Accessible by public transportation

Travel and Parking Details

There is a parking garage at the Martinos Center, for which we give parking passes at the end of each visit. Alternatively, we reimburse Ubers, Lyfts, and other types of transportation.

Additional Information

Project Website

https://redcap.partners.org/redcap/surveys/?s=N8FLEH4WWRMTPJEP


ClinicalTrials.gov Identifier

NCT04940663


Participating Institutions


Funding Source

  • NIH or Other Federal
Top