Note: This study is currently only recruiting patients in the hospital.

If you are interested in being notified if this study begins recruiting from the general population, please use the 'I Am Interested' button below.

Kidney Health in Type 2 Diabetes

Join a study to help learn about the development of kidney disease in type 2 diabetes! People with type 2 diabetes (or suspected type 2 diabetes) are needed for this study involving 3 in-person visits per year, for up to two years.

Brigham and Women's Hospital Diabetes Type 2 Chronic Kidney Disease Diabetes
3 weeks over 2 years
Estimated time commitment
Any Gender, 18-80 years
May be eligible
Payment up to $1,500
May be offered
Survey, Blood draw, Injection or IV, Office visit, Personal health tracking
May be required
 
This study is detailed for informational purposes only and may not be recruiting from the public.

Enrollment for this study is expected to close on Wednesday, January 28, 2026

Overview

What we are studying

Diabetes is the leading cause of chronic kidney disease. We want to learn more about the development and progression of chronic kidney disease in patients with diabetes. Our previous research has shown that some people make too much of a hormone called aldosterone, which can play a role in the development of high blood pressure, heart, and kidney disease. The goal of our study is to measure and follow how aldosterone behaves in people with type 2 diabetes over time (up to 2 years) to better understand why and how kidney disease may develop or progress.


Why it is important

Aldosterone is a hormone made by our adrenal glands that helps us hold on to salt. We know that too much aldosterone can cause high blood pressure and lead to heart and kidney disease in the long term.


Landmark clinical trials have recently shown that medications that block the bad effects of the hormone aldosterone can lower the risk of chronic kidney disease in patients with diabetes. 


The goal of our study is to measure and follow how aldosterone behaves in people with diabetes over time (up to 2 years) to better understand why and how kidney disease may develop. Because of the longitudinal nature of this study, our results will investigate the role of aldosterone in kidney health over time. Ultimately, our research will help inform whether medications that block the bad effects of aldosterone can be used as targeted treatments to prevent kidney disease, or the progression of kidney disease, in patients with diabetes.


What we hope to accomplish

Principal Investigator

Anand Vaidya, MD, MMSc

Brigham and Women's Hospital

Public profile

Project Contact

Click "I Am Interested" "I Am Interested" to get started.

If you have questions, contact:

BWH Diabetes Kidney Study Team

bwhaldodkd@mgb.org
(617) 732-8311

Who can participate

You may qualify if:



  • You are 18-80 years old.

  • You have a known diagnosis of Type 2 Diabetes.

  • You have a suspected diagnosis of Type 2 Diabetes (e.g., you are being treated with Metformin or other diabetes medications and/or have a known high Hemoglobin A1c).


Please fill out our screening questionnaire at: https://redcap.link/diabetes-ckd


Study staff will contact you if you are eligible for participation. You can still participate in this study even with known chronic kidney disease, up to Stage 3A.

Who cannot participate

You are not eligible for this study if you...



  • Have Type 1 or Type 3 Diabetes.

  • Are pregnant or breasfeeding.

  • Have a known history of stroke, symptomatic coronary artery disease, myocardial infarction, heart failure, or cerebral/aortic aneurysm.

  • Have an active cancer being treated with chemotherapeutic agents.

  • Are on dialysis, or have late-stage (Stage 4 or 5) chronic kidney disease.

What participants may be asked to do

If you choose to take part in this research study:



  • You would participate in 3 outpatient visits annually at Brigham and Women’s Hospital in Boston over the course of up to 2 years. 

  • These annual visits will take approximately ~3 weeks each year and are designed to help us measure how much aldosterone your adrenal glands make.

  • You will be in the study for up to two years if you decide to stay for the whole study.

  • There will be no other study visits or obligations in the intervening time between annual visits.

  • You would receive up to $750 per year in compensation, for a total of up to $1500 for completion of the two-year study, in addition to parking reimbursement for all visits.


Project activities may include:

  • Survey
  • Blood draw
  • Injection or IV
  • Office visit
  • Personal health tracking

Estimated time commitment

3 weeks over 2 years

What participants may get

Participants will receive up to $750 per year, for a total of up to $1500 for completion of the two-year study. This total is based on $250 for each of the 3 annual visits (not including screening), which are repeated once in the following 1-2 years. If you are unable to complete a particular visit, you will still be remunerated for the visits you have completed.

Location

Center for Clinical Investigation, Brigham and Women's Hospital
221 Longwood Ave, Floor 3 Boston, MA 02115

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Travel

  • Local travel reimbursed
  • Parking reimbursed
  • Parking available
  • Accessible by public transportation

Travel and Parking Details

We validate parking and/or provide up to $50 per visit for rideshare reimbursement.

Additional information

Project Website

https://redcap.link/diabetes-ckd


ClinicalTrials.gov Identifier

NCT06190158


Participating institutions


Funding source

  • NIH or Other Federal
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