Note: This study is currently only recruiting patients in the hospital.

If you are interested in being notified if this study begins recruiting from the general population, please use the 'I Am Interested' button below.

Volunteers with schizophrenia aged 18-45 needed for napping research study

We are recruiting people for a study of brain activity during naps and how it affects memory and learning.

Massachusetts General Hospital Schizophrenia MRI Scans Psychotic Disorders
4 visits
Estimated Time Commitment
Male, Female, 18-45 years
May Be Eligible
Payment up to $640, Meals
May Be Offered
Survey, Personal health tracking, Medication, Office visit, MRI scan
May Be Required
 
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This project is not recruiting.

Overview

What we are studying

We're interested in seeing whether zolpidem helps sleep and memory in healthy people and in those with schizophrenia. This study involves taking a nap after lunch while we take non-invasive recordings of your brain activity using EEG and magnetoencephalography (MEG).


Why it is important

Our findings will guide the development of treatments for sleep that will improve day-to-day function and quality of life. 


What we hope to accomplish

We hope to understand whether altering brain activity during sleep can improve learning and memory. 

Principal Investigator

Dara S. Manoach, PhD

Massachusetts General Hospital

Public Profile

Who can participate

Volunteers with schizophrenia who:


- Are willing to participate in 3 full day visits and 1 shorter 2 hour visit 
- Can sleep during the daytime

Who cannot participate

 Individuals with:


 - A history of substance abuse within the past six months, serious head injury, or seizures 

What you may be asked to do

–     Complete questionnaires
–     3 nap visits with MEG and EEG monitoring
–     10mg dose of zolpidem or placebo on two visits
–     1 MRI brain scan


–     Urine toxicology screen for drug use
–     Urine pregnancy test for women of childbearing potential
–     Wear an Actigraph wristband to monitor sleep and activity
–     Perform a task while wearing a virtual reality headset


Project activities may include:

  • Survey
  • Personal health tracking
  • Medication
  • Office visit
  • MRI scan

Estimated Time Commitment

4 visits

What You May Get

You will be compensated between $510 and $640 for completing all study tasks. Lunch and dinner will be provided based on timing of study visits.

Location

Massachusetts General Hospital
Charlestown Navy Yard149 13th St, Charlestown, MA 02129

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Travel

  • Local travel reimbursed
  • Parking reimbursed
  • Accessible by public transportation
  • Parking available

Travel and Parking Details

Additional Information

Participating Institutions


Funding Source

  • NIH or Other Federal
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